NEW STEP BY STEP MAP FOR METHADONE ADVERSE EFFECTS

[sixty one] Like a lot of other cardiotoxic drugs, methadone blocks the hERG K+ channel. The two enantiomers of methadone inhibit hERG channels with different potency. Dextromethadone, and that is fewer potent being an opioid, is much more powerful at blocking the hERG channel with an IC50 of ~12 μM. Levomethadone incorporates a lower affinity, wi